M2017
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M2017
Sigma
Mazindol
≥98% (TLC), powder
| Synonym: | 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol |
| CAS Number: | 22232-71-9 |
| Linear Formula: | C16H13ClN2O |
| Molecular Weight: | 284.74 |
| EC Number: | 244-857-0 |
| MDL number: | MFCD00864480 |
| PubChem Substance ID: | 24896596 |
Description
| Biochem/physiol Actions | Anorectic agent; inhibits the dopamine, norepinephrine and serotonin transporters with Kis of 27.6 nM, 3.2 nM, and 153 nM, respectively. |
Properties
| assay | ≥98% (TLC) |
| form | powder |
| drug control | USDEA Schedule IV; Home Office Schedule 3; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada |
| color | white |
| solubility | DMSO: 10 mg/mL |
| Gene Information | human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532) |
| rat ... Htr1a(24473), Htr2a(29595), Slc6a3(24898), Slc6a4(25553) |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | NI2975000 |
References
| reference | Smith, N.C., and Levi, R., LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. J. Pharmacol. Exp. Ther. 291, 456-463, (1999) Abstract |
| Chen, N., et al., Cationic modulation of human dopamine transporter: dopamine uptake and inhibition of uptake. J. Pharmacol. Exp. Ther. 290, 940-949, (1999) Abstract | |
| Barker, E.L., et al., High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J. Biol. Chem. 273, 19459-19468, (1998) Abstract | |
| Torres, G.E., et al., Plasma membrane monoamine transporters: structure, regulation and function. Nat. Rev. Neurosci. 4, 13-25, (2003) Abstract |
